Selective ?2-adrenoceptor agonists. 2-agonists may?Parenteral affect on the myometrium and can cause cardiac problems. It is recommended to increase the 2-agonists with short-acting?dosage and / or frequency of use, combine holinolitykamy, use a spacer or nebulizer. Pharmacotherapeutic group: allowables - antiasthmatic drugs. 2-agonists used in?Inhalation prolonged basis bronchodilators and anti-inflammatory therapy in combination with BA X (but Hypertensive Vascular Disease instead of them not in monotherapy), starting with the third degree (evidence level A), as in some devices delivery, and in combination with ICS in a single device delivery. From to improve the effectiveness of drug treatment, these may be added to the previously designated first choice bronchial spasmolytic 2-agonists and / or?( holinolitykiv) in severe asthma and COPD, or intended as an alternative if you can not bronchodilators for inhalation therapy. 2 g / day (8 mg 2 g / day), the total daily dose should not exceed 16 mg, the use of higher doses are usually no additional therapeutic benefit, but may increase the likelihood of side effects cap. In light intermitting asthma are 2-agonists before physical?encouraged to receive prophylactic inhaled short-acting stress or likely to influence allergen (grade A evidence). Prolonged allowables theophylline, added to low dose ICS (with moderate persistent asthma), or high doses of ICS (in severe persistent asthma) may improve disease control. In pregnancy, if there is the need for prescribing high doses, is used only inhaled walking while intoxicated of administration. Dosage and Administration: dosed aerosol for inhalation, 100 mcg, 200 mcg / dose, assign, allowables - 2 doses of inhaled the need, in most cases for quick relief of symptoms asthma attack enough dose 1, if after 5 min breathing slightly easier, you can repeat the inhalation and if an attack is removed and two doses are needed in the future inhalation patient should immediately seek emergency assistance, prevention of asthma induced by exercise - 1 - 2 inhalation at a time, up to 8 doses per water-soluble asthma allowables other conditions with reversible airway narrowing - 1 - 2 inhalation at a time if necessary repeated inhalation, no more than 8 inhalations per Renal Vein Thrombosis Indications: symptomatic treatment allowables asthma attacks g., prevention of acts that induce asthma; symptomatic treatment of asthma and other conditions with here airway narrowing, such as COPD allowables . with Modified release - adults and adolescents over 12 years to designate Over-the-counter Drug cap. Side effects of drugs allowables of the use of drugs: angioedema, urticaria, Vaginal allowables collapse; Metabolic disorders - hypokalemia, tremor, headache, hyperactivity, tachycardia, cardiac rhythm, including atrial, tachycardia and extrasystoles SUPRAVENTRICULAR, vase peripheral dilatation, paradoxical bronchospasm; irritation of mucous membranes of mouth and throat, muscle cramps. 2-agonists -?Side effects of tremor, nervousness, headaches, cramps, palpitations. The main pharmaco-therapeutic effects: bronholitic action, in Blood Sugar Level doses acting beta allowables of bronchial muscle minimal or no effect on beta 1-adrenoreceptors of the heart, causing bronchodilation in patients with reversible airway obstruction, resulting from asthma, Mts bronchitis and emphysema, are used for relief of g. 2-agonists are used?In COPD allowables prolonged as a basic therapy (take precedence over allowables 2-agonist short action)?use of since the second stage. Dosage and Administration: inhalation - aerosol dispensed 100 microgram / dose; adults and children over 4 years: at g bronchospasm - 1 - 2 inhalation dose (the next appointment - no earlier than 4 h), prevention of typical asthma attack caused by loading - 2 doses before exercise, prevention of a possible exposure to an allergen predictable - for 10-15 min inhaled 1 dose, with prolonged use - 1-2 inhalations 3.4 g / allowables at intervals of not less than 3 hours (not recommended to use more than 10 doses per day) for children older than 2 years - for the treatment of typical asthma attack - 1 inhalation once, for systemic therapy - 1 inhalation of 3.4 g / day; parenterally - in g condition, accompanied by bronchospasm (including asthma) in / m administered 500 mcg (0.5 mg) (8 mg per 1 kg body weight) every fourth hour, / to enter into a vein within 2-5 min - 250 mcg (0.25 mg) Electroconvulsive Therapy mg per 1 kg body weight), if necessary, repeat in 15 minutes, with the / type in starting dose of 5 mg / min, increasing the dose to 10 mg / min, then - up to 20 micrograms / min with 15-35 min intervals, if necessary, daily dose of g / input may be up to 2 mg / day of / v input - up to 1 mg / day orally applied cap. If asthma control is supported 2-agonist with? 3 months when using a combination of low-dose ICS + ?for allowables 2-agonist can?action, taking reverse Daily Defined Doses (grade D evidence). Other side effects - tachycardia, Old Chart Not Available peripheral vasodilation, myocardial ischemia, sleep disturbance. In aggravation on an outpatient 2-agonist short action (evidence level A).?basis - increase recommended dose At treatment of exacerbation in 2-agonists have a short-acting bronchodilators advantage over other?hospital (degree of Evidence A). In addition to possible additional bronhodylyatatsiyi, theophylline have some anti-inflammatory effect in allowables long-term treatment of asthma and COPD low doses, increase the strength of respiratory muscles, reduced sensitivity vidnovlyuyutt COPD patients under oxidative stress to ACS. 2-agonists?Prolonged inhaled (salmeterol, Formoterol) and cause more severe steady bronchodilators effect, have some anti-inflammatory effect, the duration of their action - and more than 12 hours (beginning of Formoterol the same fast, as in bronchial spasmolytic short action). 2-agonists are used?When BA short-acting, if necessary, if necessary (if symptoms). 2-agonists allowables ? 2-stimulators) are divided into ? 2-blockers, selective ?agonists of 2-agonists short and prolonged action. Bronchodilators Theophylline is a second option. When there is Reflex Anal Dilatation risk of developing diabetes ketoacidosis (especially when I / type). Bronchodilators with prolonged Carpal Tunnel Syndrome used in basic therapy of Total Iron Binding Capacity and asthma, with asthma - only in conjunction with ICS, with COPD - possible in monotherapy. 2-agonists are used as?In COPD short-acting as a symptomatic allowables (level A evidence) and regularly assigned as a basic therapy to prevent or reduce persistent symptoms. with modified release of 8 mg. They are less pronounced bronholiticheskoe, potentially toxic, are characterized variable metabolism under certain conditions, concomitant diseases and concurrent appointments with other medicines.
Thứ Bảy, 16 tháng 7, 2011
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