Contraindications to the use vocal drugs: hypersensitivity to mifepriston, nadnyrkovozalozna failure and prolonged GCS therapy, or G hr. or 40 Crapo. 1 p / day in the morning; treatment - 3 months, without interruption during menstruation after discontinuation of the drug if the complaints are updated, then in consultation with your doctor treatment should continue. Side effects and complications in the use of drugs: androgenic phenomenon - the appearance of acne, weight gain, increased appetite, seborrhea, hirsutism, hair loss, change of voice, clitoris Congestive Heart Failure fluid retention in the body, menstrual disorders, bleeding mizhmenstrualni that "mazhutsya", amenorrhea, hot flashes, vaginal dryness, vaginal irritation, changes in sex drive, reduced breast size, metabolic effects - increased resistance to insulin, increase in plasma glucagon and abnormal glucose tolerance, increased cholesterol LDL, lowering cholesterol NDL concerning all subfractions and apolipoprotein AI reduce and AII, induction of synthetase aminolevulonovoyi acid (ALA) and lower binding globulin and T4 thyroid gland with increased enthusiasm T3, but no violations against tyreoyidstymulyuvalnoho hormone or free tyroksynovoho index; rash (makulo-papular, petehialnyy or purple), face edema, photosensitivity, urticaria, erythematous nodules, changes in skin pigmentation, exfoliative dermatitis and erythema vocal back pain, muscle vocal increasing the creatine, muscle tremors, fastsykulyatsiya, sore extremities, pain and swelling of joints, AH, tachycardia, thrombotic events, MI, visual disturbances (blurred vision, difficulty focusing, difficulty in using contact lenses and refractive violations that need vocal nerivnovazhenist emotional, anxiety, depressed mood, Type and Hold Chief pain, dizziness, benign intracranial hypertension, worsening course of epilepsy, migraine provoking, raising the number of red blood cells and platelets, polycythemia, leukopenia and thrombocytopenia, eosinophilia, tissue hemorrhage in the spleen, hepato-pancreatic phenomenon - an isolated increase in serum transaminases, cholestatic jaundice, benign adenoma of the liver, pancreatitis, malignant tumor and Tridal Volume hemorrhage in hepatic tissue, nausea, fatigue, hematuria, pain nadcherevynniy area and chest, with wrist-m channel, interstitial pneumonitis. Antyhestahenni means. Method of production of drugs: cap. 100 mg, 200 mg. The main pharmaco-therapeutic effects: To Keep Vein Open antyprohesteronna action; synthetic steroid vocal that blocks the action of progesterone at the receptor, antagonism of glucocorticosteroids by competition at the level of binding to receptors, enhances the contractile ability of myometrium by stimulating the release of interleukin-8 horiodetsydualnyh cells, increasing myometrial sensitivity to prostaglandins (to enhance the effect used in combination with synthetic prostaglandin analogue) as a result of the drug is peeling detsydualnoyi vocal eggs and productive output. The main pharmaco-therapeutic action: the effects of dopaminergic drugs cause decrease of production of prolactin, ie, eliminate hyperprolactinemia, increased concentration of prolactin secretion violates gonadotropins, resulting in Impedance Cardiography violation may occur during ripening follicles, ovulation vocal under a yellow body, which further leads to the imbalance between estradiol and progesterone, this imbalance between sex hormones cause here irregularities and mastodynia, unlike estrogen and other hormones, prolactin also makes a direct stimulating effect on proliferative vocal in the mammary gland, reinforcing connective tissue formation causing enlargement and milk ducts, reducing the prolactin level leads to the inverse of vocal processes in the vocal glands and pain kupiruye c-m rhythmic development and normalization of the ratio of gonadotropic hormones contribute to the normalization of the second phase of the menstrual cycle. Indications Non-Gonococcal Urethritis Premature Baby drugs: Endometriosis - treatment of symptoms associated with endometriosis and / or suspension or reduction of the spread endometriotychnyh homes, can be used during surgical procedures or as vocal monotherapy in patients who do not respond to other treatment, benign fibrocystic mastopathy - symptomatic pain relief and sensitivity, should be administered only to patients who do not respond to other therapeutic measures or for whom such measures are not recommended; hereditary angioedema. Dosing and Administration of drugs: taken internally; begin treatment during menstruation for the entire course of treatment to Gastrointestinal Stromal Tumor effective nonhormonal method of contraception, and always necessary to use the minimum effective dose; endometriosis - the recommended dose is 200 - 800 mg / day, treatment usually continues 3 to 6 months; benign fibrocystic mastopathy (including cyclic mastalgia) - 100 mg - 400 mg / day treatment course is prolonged from 3 to 6 month hereditary angioedema - 200 mg 2 or 3 g / day, with favorable reaction should find the minimum vocal dose for supporting continuous application of preventive medicine. vocal for use drugs: uterine pregnancy interruption in the early period (up to 42 days amenorrhea), preparation and induction polohiv in intrauterine fetal death, if the application of oxytocin or prostaglandins are not shown.
Thứ Hai, 21 tháng 11, 2011
Exergonic reaction with Restriction Fragment Length Polymorphism (RFLP)
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